Abstract
The protective effect of hidrosmin (O-(β-hydroxyethyl)diosmin) against cisplatin-induced renal toxicity in male Wistar rats after a single intravenous injection of 6 mg kg−1 cisplatin was studied. Over six days, cisplatin-treated animals developed changes in total body weight and absolute kidney wet weight, and an increase in functional indices of nephrotoxicity such as plasma urea nitrogen and creatinine. Hidrosmin (0.3, 1 and 3 g kg−1) administered orally during six consecutive days preserved renal function in cisplatin-treated rats in a dose-dependent manner. Hidrosmin protection may be mediated by a free radical scavenging activity.
Full Text 
Sign-in/Register to access full text options
Sign-in/Register to access full text options 
Published version (
Free)
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
