Protective Effect of Rutin against Cisplatin-Induced Nephrotoxicity in Rats

Abstract

Objective: To study the nephroprotector activity of the bioflavonoid, rutin (50 and 100 mg/kg, p.o.) on cisplatininduced nephrotoxicity (6mg/kg, i.p.) in albino rats. Materials and Methods: Nephroprotector activity of rutin was assessed by estimating the levels of blood urea nitrogen, serum creatinine, serum total proteins, urinary protein, creatinine clearance, urine to serum creatinine ratio and lipid peroxidation in kidney. Results: Cisplatin elevated the serum markers level, increased the protein excretion in urine, reduced the creatinine clearance, urine to serum creatinine ratio and renal malondialdehyde level was increased. Animals which received rutin, in curative and prophylactic groups significantly reversed the effects induced by cisplatin. Conclusion: From the results it is revealed that rutin effectively reduced the cisplatin-induced renal toxicity in albino rats.