Protective Effect of Herbal Medicinal Plant Extract against Carbon Tetrachloride Induced Liver Injury in Rat

Abstract

Adiantum capillus (AC) Linn (Family: Adiantaceae) commonly known as “Hansraj” It is used in common cold, cough, pyrexia inflammation, acts as purgative. It improves digestion and renal function.  This study was performed to investigate the hepato-defensive potential of Adiantum capillus in contradiction of carbon tetrachloride tempted hepatic damage in rats. The rodents were dosed with Acetonic extract (AEAC, 500mg/kg) extract of Adiantum capillus against Carbon Tetrachloride induced hepatic damage. Results shows thst Carbon Tetrachloride elevated the level of hepatic markers like SOPT, SGPT, bilirubin and ALP as well as altered the antioxidant enzymes. The level of hepatic biomarkers, as well as antioxidant enzyme, were recovered after the administration of at 500mg/kg, p.o., which was further confirmed by the histopathological. From above results it was concluded that The Acetonic extract (500 mg/kg, bw) extract of Adiantum capillus (ACE) recover the biochemical as well as antioxidant parameters, which were affected by Carbon Tetrachloride. The histopathological analysis supports the outcomes of antioxidants parameters.
 Key Words: Adiantum capillus, , , x, ,