Abstract
We investigated the protective effects of curcumin on propanil-induced alterations in biochemical indices in blood and liver of male Wistar rats. The study consisted of four treatment groups, with six animals each, designated as control, propanil (20mg/kg), curcumin(50 mg/kg), and curcumin (50 mg/kg) + propanil (20 mg/kg). Rats were administered their respective doses orally, every other day, for 28 days. Propanil administration elicited significant (P < 0.001) increases in plasma aspartate aminotransferase and alkaline phosphatase activities, by 24% and 56%, respectively, compared to the control. Treatment with propanil elevated bilirubin, creatinine, and total cholesterol levels in rats, but these were not significant relative to controls. Administration of propanil to rats significantly (P < 0.001) increased lipid peroxidation levels. However, catalase activity, vitamin C, and reduced glutathione levels were significantly reduced. Exposure to propanil did not produce any significant changes in packed cell volume, neutrophils, and leukocyte counts. The supplementation of curcumin attenuated the adverse effects of propanil intoxication by reducing lipid peroxidation levels and restored the levels of serum enzymes and reduced glutathione. The present study showed that propanil increased oxidative stress and altered some biochemical parameters in the rats but curcumin could afford some protection to attenuate propanil-induced toxicity in the liver.
Highlights
IntroductionCurcumin (diferuloylmethane) is a yellow colouring ingredient of the spice turmeric obtained from the rhizome of Curcuma longa Linn (Zingiberaceae)
Curcumin is a yellow colouring ingredient of the spice turmeric obtained from the rhizome of Curcuma longa Linn (Zingiberaceae)
Evaluation of plasma marker indices in rats exposed to propanil (20 mg/kg/bodyweight) showed that there were significant (P < 0.001) increases in AST and Alkaline phosphatase (ALP) activities by 24% and 56%, respectively, when compared with controls (Figure 1)
Summary
Curcumin (diferuloylmethane) is a yellow colouring ingredient of the spice turmeric obtained from the rhizome of Curcuma longa Linn (Zingiberaceae). It is a perennial herb distributed mainly throughout tropical and subtropical regions of the world [1]. Curcumin possesses anti-inflammatory, immunomodulatory, and antiatherogenic activities and is a potent inhibitor of various reactive oxygen-generating enzymes [2, 3]. It has been used in indigenous herbal medicine for the treatment of inflammatory and liver disorders. Canales-Aguirre and coworkers [11] had reported the protective effects of curcumin against the oxidative damage in the hippocampus of rats after exposure to parathion
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
