Protective effect of coenzyme Q10 nanoparticles against monocrotophos induced oxidative stress in kidney tissues of rats

Abstract

The present study evaluated the effect of coenzyme Q10 nanoparticles (CoQ NPs) against monocrotophos (MCP) exposure-induced oxidative stress in kidney tissue of rats. Albino wistar rats were divided into four groups i.e. control, CoQ NPs-treated, MCP-treated and MCP + CoQ NPs-treated groups. An acute dose of MCP (4.5 mg/kg b.wt) dissolved in corn oil was administered while CoQ NPs were given at a dose of 100 mg/kg b.wt 2 h before MCP treatment. Results showed that MCP exposure resulted in oxidative stress generation in kidney tissue of rats as depicted by increased lipid peroxidation and protein oxidation followed by decreased glutathione content in tissue homogenate. The activity of superoxide dismutase also decreased significantly in kidney tissue. Histopathological analysis showed many cellular alterations in the kidney tissue supporting the toxic effects of MCP exposure in rats. Co-treatment of CoQ NPs with MCP significantly ameliorated the oxidative stress generation and improved the histological alterations. The results indicate that CoQ NPs have the potential to reverse the oxidative stress generated after MCP exposure in rat kidneys suggesting their therapeutic potential.