Coenzyme Q10 nanoparticles prevents monocrotophos exposure mediated neurotoxicity by attenuating the histological alterations in rats

Abstract

Organophosphate (OP) insecticide monocrotophos (MCP) is extremely hazardous to all living beings. This study shows that coenzyme Q10 nanoparticles (CoQ10NPs) can protect rats from the neurotoxicity caused by MCP-induced oxidative stress. In this study, male albino rats were divided into six groups i.e. control, CoQ10NPs low dose (50mg/kg b. wt) treated group, CoQ10NPs high dose (100mg/kg b. wt) treated group, MCP (4.5mg/kg b. wt) exposed group, CoQ10NPs low dose + MCP (50mg and 4.5mg/kg b. wt) treated group and CoQ10NPs high dose + MCP (100mg and 4.5mg/kg b. wt) treated group. The observation showed the depletion in the level of AChE activity and elevation in the levels of protein oxidation and lipid peroxidation which indicated the emerging of oxidative stress resulting in the induction of neurotoxicity. A significant decrease in the level of various enzymatic and non-enzymatic antioxidants like glutathione (GSH), catalase and superoxide dismutase (SOD) was observed in rat brain. The histopathological study indicated the major structural alterations in neuronal tissues of rats. These additionally backed up the induction of toxic effects caused by MCP exposure in rats. The prior co-treatment of CoQ10NPs along with MCP exposure depicted the significant protection from the oxidative stress generation and improved the structural and histological alteration in the rat brain. Hence, it can be concluded that CoQ10NPs have the strong therapeutic potential to reduce the MCP-induced oxidative stress, indicating their protective effects against MCP-induced neuronal cell damage in rats.