Abstract
Carboxymethyl-glucan (CM-G) is a soluble derivative from Saccharomyces cerevisiae (1 → 3)(1 → 6)-β-D-glucan. The protective efficiency of CM-G against DNA damage in cells from patients with advanced prostate cancer (PCa), and undergoing Androgen Deprivation Therapy (ADT), was evaluated. DNA damage scores were obtained by the comet assay, both before and after treatment with CM-G. The reduction in DNA damage, ranging from 18% to 87%, with an average of 59%, was not related to the increased number of leukocytes in peripheral blood. The results demonstrate for the first time the protective effect of CM-G against DNA damage in patients with advanced PCa. Among smokers, three presented the highest reduction in DNA damage after treatment with CM-G. There was no observable relationship between DNA damage scores before and after treatment, and age, alcoholism and radiotherapy.
Highlights
B-D-glucan from the cell wall of Saccharomyces cerevisiae is a polymer composed of repeating glucose units, and organized into a central skeleton linked by b (1 ® 3) glycosidic bonds, with side chains of variable sizes joined by b (1 ® 6) linkages (Di Luzio et al, 1979)
As the benefits arising from the biological activity of (1 ® 3)(1 ® 6)-b-D-glucan are limited by its insolubility in water, studies are under way with derivatives of this polymer in an attempt to improve its availability
We believe that treatment with CM-G can be an efficient protection against DNA damage caused by mutagenic compounds through dismutagenic activity, either by its capability of blocking the action of damage-inducing agents, or by bio-antimutagenic activity, which exerts its effect by preventing damage or promoting DNA repair, since Oliveira et al (2007) showed that this is a characteristic of (1 ® 3)(1 ® 6)-b-D-glucan from S. cerevisiae
Summary
Protective effect of carboxymethyl-glucan (CM-G) against DNA damage in patients with advanced prostate cancer.
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