Abstract
Tuberculosis is one of the bacterial infection caused by mycobacterium tuberculosis strain and the treatment for it involves the use of anti-tubercular drugs. Rifampicin is one of the common drug that is used for tuberculosis but it potentiates liver toxicity due to metabolism. Objective: The present study was designed to Check the a hepatoprotective agent from a natural source. The natural source was chosen to minimize the side effects that occur due to conventional or synthetic drugs. The hepatoprotective activity of 70% ethanol extract of Blumea lacera leaves (EEBLL) was evaluated against Rifampicin induced hepatotoxicity in rats. Preliminary phytochemical screening, acute oral toxicity, in vivo antioxidant activity, physical and Biochemical parameters were evaluated for hepatoprotective activity. Preliminary phytochemical screening revealed that flavonoids, tannin and saponins are present in EEBLL. Acute oral toxicity was performed as per the Organization for Economic Co-operation and Development (OECD) guidelines and selected doses of 200 and 400 mg/kg. In rifampicin induced hepatotoxicity in rats, the effect of EEBLL on the biochemical parameters (SGOT, SGPT, ALP, direct and total Bilirubin) was assessed. The increased levels of the above-mentioned biochemical indicators of hepatotoxicity were significantly normalized after the pretreatment with EEBLL (200 mg/ kg and 400mg/kg). The histopathological studies also supported above findings. It is concluded from this study that EEBLL possesses hepatoprotective properties which may be attributed to the polyphenolic compounds that are present in the plant. Further isolation and characterization are required to identify the potent compound as hepatoprotective.
Highlights
Rifampicin is the first line drug to treat tuberculosis (TB) due to its efficacy, but its major adverse effects cause liver diseases [1]
In view to develop potent hepatoprotective agent from natural source against rifampicin induced hepatotoxicity in albino rats, the efficacy of Blumea lacera was investigated in rats
Administered Rifampicin is metabolized to active compound diacetyl rifampicin
Summary
Rifampicin is the first line drug to treat tuberculosis (TB) due to its efficacy, but its major adverse effects cause liver diseases [1]. Viral hepatitis, hepatocellular carcinoma and alcohol-associated liver disease etc., are responsible for approximately 2 million deaths every year. Diabetes, viral hepatitis and druginduced hepatotoxicity are a major concern. To overcome the major adverse effect of rifampicin and other drugs induced liver damage, available conventional or synthetic hepatoprotective drugs are sometimes insufficient and may induce adverse effects. In view to develop potent hepatoprotective agent from natural source against rifampicin induced hepatotoxicity in albino rats, the efficacy of Blumea lacera was investigated in rats
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