Abstract
Abstract : This report describes the development of the parenchymal marker technique which makes it possible to reconstruct 3-dimensional shapes and dimensions of the heart, lung, chest-wall and diaphragm in the intact thorax. The technique presents a unique opportunity to study dynamic regional lung mechanics and lung-chest wall-diaphragm interaction under various conditions of lung volumes and body position and thereby provides the methodology to study the effects on regional lung function of alterations in these parameters induced by changes in the gravitational-inertial force environment. Significant new information has been obtained regarding regional mechanical properties of the lung with techniques possessing sufficient temporal and spatial resolution to permit quantitative determination of the dynamic changes in spatial (three-dimensional) lung parenchymal strains, regional lung volumes and lung-chest wall geometries. Such mechanical studies of the intact lung have not been possible, heretofore, these new results provide a quantitative measure of the mechanical properties of the lung under normal physiologic conditions (i.e., an intact thorax and normal intrathoracic pressures) at 1G and are required before similar studies can be performed under conditions of increased or decreased gravitational-inertial force environments encountered in aerospace flight.
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