Abstract
The purpose of this study was to know the effect of Dayak onion tuber extract (Eleutherine palmifolia) given by per oral in lowering levels of histophatology damage kidney of albino male rat (Rattus norvegicus) strain Wistar which was induced by alloxan. Animals which were used in this research were 24 white male rats (Rattus norvegicus) strain Wistar, and then divided into 6 groups. The negative control group K (-) were given with aquabidest and CMC-Na 1% during the therapy period, the positive control group K (+) were given with alloxan 110 mg / kgbw, the group of drug control K (O) were given with alloxan and oral therapy with metformin 9 mg / 200g bw / day, the treatment group 1 (P1) were given with alloxan and per oral therapy with extract of Dayak onion tuber 100 mg / kgbw, the treatment group 2 (P2) were given with alloxan and per oral therapy with extract of Dayak onion tuber 200 mg / kgbw and the treatment group 3 (P3) were given with alloxan and per oral therapy with extract of Dayak onion tuber 400 mg / kgbw. The therapy was given for 14 days, then the animals were sacrificed with ketamine and then its kidney was taken for examination of hisphatology in kidney. Observations based on their depiction of renal histopathology tubular degeneration and necrosis, glomerular necrosis, intestitial infiltration and glomerular sclerosis. Data obtained from the scoring of histopathological appearence albino rat kidneys were analyzed by test Kruskal-Wallis and if there is a real difference followed by Mann-Whitney test using SPSS 20.0 for windows. The results showed that the extract of Dayak onion tuber 400 mg/ kgbw can reduce the degree of kidney damage in albino male rat exposed to alloxan significantly. Key words: Eleutherine palmifolia, alloxan, kidney, histhopathology
Highlights
Diabetes mellitus has low concentrations of the hormone insulin, so blood sugar levels will be high
In the condition of high glucose levels in the blood can cause the formation of Reactive Oxygen Species (ROS) that result in oxidative stress
The dosage of Dayak bulb extract (Eleutherine palmifolia) 100, 200 and 400mg / kgBB peroral and each dose of extract will be dissolved in CMC-Na in 3 treatment groups
Summary
Diabetes mellitus has low concentrations of the hormone insulin, so blood sugar levels will be high. [6] Onion Dayak or ghost onion (Eleutherine palmifolia (L.) Merr) is a typical plant of Central Kalimantan. One of the alternative treatments to replace chemical drugs is to use traditional medicinal plants that can prevent and treat diabetes mellitus. This plant has been used for generations of Dayak community as a medicinal plant. The compound of this polyphenol derivative is capable of stabilizing and removing unpaired electrons and capable of counteracting free radicals [8]
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