Abstract
This study aimed to determine changes in testicular histopathological of the rat strain wistar diabetes mellitus experienced. This study used 24 white rats (Rattus norvegicus) strain Wistar which were divided into six groups: administration of Moringa oleifera leaves P1 (extract dose 0 mg/kg bw) , P2 (100 mg/kg bw) , P3 (200 mg/kg bw), P4 (300 mg/kg bw) , P5 (400 mg/kg bw) and P6 ( 500 mg/kg bw) . In the end of administration, the diabetic Wistar rats were sacrificed and their testes were taken to make the histopathological preparations using haematoxylin and eosin staining. The observed variables are fat degeneration and necrosis. The results show that moringa leaves can improve histopathology testis structure of diabetes mellitus white rats. Extract of Moringa leaves (Moringa oleifera) dose of 400 mg/kg body weight has the best effect repair damage to the histopathological testis.
Highlights
Diabetes mellitus (DM) merupakan suatu penyakit yang melibatkan hormon endokrin pankreas, antara lain insulin dan glukagon
This study used 24 white rats (Rattus norvegicus) strain Wistar which were divided into six groups: administration of Moringa oleifera leaves P1, P2 (100 mg/kg bw), P3 (200 mg/kg bw), P4 (300 mg/kg bw), P5 (400 mg/kg bw) and P6 ( 500 mg/kg bw)
The results show that moringa leaves can improve histopathology testis structure of diabetes mellitus white rats
Summary
Dua puluh empat ekor T ikus putih jantan, umur 3-4 bulan dengan berat badan 200-250 gram. dibagi menjadi 6 kelompok berdasarkan dosis pemberian yaitu kelompok P1 (diabetes kontrol, ekstrak daun kelor dosis 0 mg/kg bb/hari), kelompok P2 (ekstrak daun kelor dosis 100 mg/kg bb/hari), kelompok P3 (ektrak daun kelor dosis P4 mg/kg bb/hari), kelompok P4 (ektrak daun kelor dosis 300 mg/kg bb/hari), kelompok P5 (ektrak daun kelor dosis 400 mg/kg bb/hari), dan kelompok P6 (ektrak daun kelor dosis 500 mg/kg bb/hari) selama 5 minggu.
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