Abstract
Myrica rubra (MR) is rich in anthocyanins, and it has good anti-cancer, anti-aging, antioxidant, and antiviral effects. The proportion of disability and death caused by ischemic stroke gradually increased, becoming a major disease that is harmful to human health. However, research on effects of anthocyanin from MR on cerebral ischemia-reperfusion (I/R) injury is rare. In this study, we prepared eight purified anthocyanin extracts (PAEs) from different types of MR, and examined the amounts of total anthocyanin (TA) and cyanidin-3-O-glucoside (C-3-G). After one week of PAE treatment, the cerebral infarction volume, disease damage, and contents of nitric oxide and malondialdehyde were reduced, while the level of superoxide dismutase was increased in I/R mice. Altogether, our results show that Boqi1 MR contained the most TA (22.07%) and C-3-G (21.28%), and that PAE isolated from Dongkui MR can protect the brain from I/R injury in mice, with the mechanism possibly related to the Toll-like receptor 4 (TLR4)/ nuclear factor-κB (NF-κB) and NOD-like receptor pyrin domain-containing 3 protein (NLRP3) pathways.
Highlights
Stroke is one of the most common causes of adult disability and death worldwide, with more than 80% of all cases triggered by ischemic events
All mice were randomly divided into five groups (n = 10) as follows: normal control (NC), treated with a saline solution and a sham operation; I/R, treated with a saline solution and cerebral ischemia-reperfusion injury; and purified anthocyanin extracts (PAEs) 100, PAE 150, and PAE 300, treated with 100 mg/kg, 150 mg/kg, and 300 mg/kg PAE, respectively, from Dongkui Myrica rubra every day, as well as cerebral ischemia-reperfusion injury
Myrica rubra (MR) is rich in anthocyanins, with >95% being C-3-G [5,14]
Summary
Stroke is one of the most common causes of adult disability and death worldwide, with more than 80% of all cases triggered by ischemic events. Along withnatural chlorophyll and carotenoid, are known the carotenoid,bonds they are known as the three major pigments, and can be they divided into sixas main three major natural pigments, and can be divided into six main anthocyanin groups according to anthocyanin groups according to their substituent groups (Figure 1). We prepared and analyzed eight kinds of purified anthocyanin extracts (PAEs) from different extracts from different of MR, their protection and to mechanism withinjury, regards to varieties(PAEs) of MR, studied theirvarieties protection andstudied mechanism with regards cerebral I/R and cerebral injury, andbasis provided a theoretical basis for daily life and clinical research. ProvidedI/R a theoretical for daily life and clinical research
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
