Protease‐Sensitive, VEGF‐Mimetic Peptide, and IKVAV Laminin‐Derived Peptide Sequences within Elastin‐Like Recombinamer Scaffolds Provide Spatiotemporally Synchronized Guidance of Angiogenesis and Neurogenesis (Adv. Healthcare Mater. 22/2022)

Abstract

Elastin-Like Recombinamers In article 2201646 by José Carlos Rodriguez-Cabello and co-workers, a 3D model scaffold containing two cylindrical elastin-like recombinamer (ELR) hydrogels embedded in a slow-resorbable or nonprotease-sensitive ELR hydrogel that allow the independent spatiotemporal control of angiogenesis and neurogenesis in vivo, by the combination of protease-sensitive sequences, with fast and slow degradation kinetics, a VEGF-mimetic peptide (QK), and a laminin-derived peptide (IKVAV), is developed.