Abstract
Background Malignant gliomas are dense vasculized tumors and express high levels of vascular endothelial growth factor (VEGF) families. Although the induction of angiogenesis via VEGF family is well elucidated and anti-VEGF therapy is thought attractive, the VEGF inhibitors show limited efficacy. Various induction systems of angiogenesis except VEGF families are presumed to act in malignant gliomas. Prostate specific membranous antigen (PSMA) is expressed by endothelial cells of neovasculature but not in normal endothelial cells. In this study, to elucidate the roles of PSMA on angiogenesis in malignant glioma, we performed IHC for PSMA, VEGF-A, and Aquaporine-4 (AQP4). Materials and methods Twenty archived samples were used. Tissues were composed of eighteen malignant gliomas (Grade 3 to 4) and two normal cerebral tissues as control. Microscopic slides were stained using HE, and immunohistochemistry. Results Positive findings for VEGF were recognized in glioma cells and endothelial cells of neovasculature. But PSMA positive endothelial cells were also recognized in same cases. There was no positive staining for PMSA in endothelial cells of controls. Conclusion Angiogenesis and vasculogenesis in malignant glioma were composed of various factors. PSMA was one of the major factors of formations of neovasculature. Strategies using anti-PSMA agents were anticipated new treatments for malignant gliomas.
Published Version
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