Abstract
Prostate cancer (PCa) is one of the burgeoning cancers worldwide. Of late, the number of cases in the Indian subcontinent has been doubling and the incidence as per the population-based cancer registries (PBCR) has increased at an alarming rate. In assessing the trends of PCa, there needs a statistical framework on incidence, comparing PBCRs vis-a-vis with hospital-based cancer registries not only to that of cohorts from India but also to that of West and other consortia. Our erstwhile pilot study on inferring whole-exome sequencing variants has yielded distinct polymorphisms in the Indian phenotype of PCa. There are impending challenges and gray areas that we discuss in this review in lieu of PCa pathogenesis and therapeutics.
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