Abstract
Prostate cancer and new insights in angiogenesis.
Highlights
Angiogenesis is considered one of the hallmarks of tumor initiation and progression it is the widely accepted therapeutic target
Angiogenic switch by its definition implies impaired angiogenesis and importance of high vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) levels holding responsible for PCA progression [6]
Hypoxic state is informative as relative tissue oxygenation status, which correlates with overall VEGF expression in prostate [7,8,9,10]
Summary
Angiogenesis is considered one of the hallmarks of tumor initiation and progression it is the widely accepted therapeutic target. Cancer cells acquire several distinct morphological alterations increasing their capacity to proliferate and independently sustain growth, and at the same time, inhibit homeostatic, physiologic signals from the microenvironment they are in, and under the control of which they should have remained.
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