Prostat Karsinomunda Enerji Metabolizmasının Yeniden Programlanması: İn Siliko Analiz

Abstract

Prostate carcinoma is known to be a hypoxic and lipogenic solid tumor, exhibiting a remarkable oncogenic modulated metabolic programming. Increasing intake of glucose and aerobic glycolysis, called the Warburg effect, are main metabolic changes in hypoxic tumors. Protein,nucleid acid , and lipid biosynthesis are the other metabolic processes associated with cancer metabolic rewiring. In addition to “Warburg effect” in prostate carcinoma, fatty acids, glutamine, and mitochondrial oxidative phosphorylation in alternative metabolic pathways are considered main contributors to tumorigenesis. The aim of this study is to investigate reprogramming of energy metabolism in well and poorly differentiated prostate carcinomas with seminal vesical invasion. The GSE32448 gene’s microarray data were downloaded from the "Gene Expression OmniBus". Differences in gene expression levels were generated by re-analyzing the mRNA transcripts of tissues obtained from 40 patients specimens. "Biobase", "Limma" and "Geoquery" libraries were obtained with bioinformatics analysis using R program. Statistically significant differences were found in genes related to fatty acid metabolism. Increased awareness of the role of lipid metabolism in prostate cancer can lead to developing better treatment strategies against this malignancy.