Abstract 4526: Attenuation of hypoxia in solid tumor with multifunctional upconversion nanoparticles to enhance photodynamic therapy

Abstract

Abstract As a non-invasive therapeutic technique, photodynamic therapy (PDT) requires sufficient oxygen in order to generate adequate singlet oxygen upon the excitation of photosensitizer using an appropriate light wavelength. It has limited efficacy in preexisting hypoxia in tumor and PDT-induced hypoxia, owing to the limit oxygen level in the tissue and the consumption of the oxygen during the PDT treatment. Herein, taking advantage of hyperbaric oxygen (HBO), multifunctional upconversion nanovehicle is constructed to overcome the above-mentioned problems. HBO provides timely oxygen supply during the treatment, which greatly enhances the photodynamic effect of the loaded nanoparticles, as demonstrated by the accelerated generation of 1O2 and elevated cytotoxicity. Tumor growth is greatly regressed in the HBO-PDT treated mice. Our finding provides new insights into the modulation of unfavourable tumor microenvironment with the perfect marriage between HBO and NIR-light sensitized upconversion nanoparticles to overcome the current limitation of cancer photodynamic therapies. Note: This abstract was not presented at the meeting. Citation Format: Yan Zhang, Jingqiu Li, Jun Hu, Xiangliang Yang. Attenuation of hypoxia in solid tumor with multifunctional upconversion nanoparticles to enhance photodynamic therapy [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 4526. doi:10.1158/1538-7445.AM2017-4526