Abstract
Prostaglandin-I Synthase (PGIS) is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases, which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids. However, PGIS is considered to be a member of the cytochrome P450 superfamily on the basis of its sequence similarity rather than functional similarity. This membrane protein, located in the endoplasmic reticulum, catalyzes the conversion of prostaglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis.
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