Abstract
Prostacyclin is a potent vasodilator and inhibitor of platelet aggregation. Prostacyclin synthase (PGIS), which converts prostaglandin H2to prostacyclin, is a member of the cytochrome P450 superfamily. We report here the characterization of the human PGIS gene. The gene is about 60 kb long and contains 10 exons. The PGIS gene was assigned to chromosome 20 by analysis of a human-hamster somatic hybrid DNA panel. The transcription start site was identified by primer extension, and approximately 3 kb of DNA upstream of this site was sequenced. The region surrounding the transcription start site presents features characteristic of a house-keeping gene promoter. It lacks a TATA box but is very rich in GC content. Several putative potential binding sites for transcription factors were identified.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Biochemical and Biophysical Research Communications
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
