Abstract
THE presence of small quantities of prostaglandin-like material has been demonstrated in medullary carcinoma of the thyroid1 and in Kaposi's sarcoma2; the diarrhoea often associated with these tumours has been attributed to prostaglandins. Diarrhoea is also often present in mice bearing the BP8/P1 tumour. Preliminary investigations of the ascitic fluid from mice inoculated with this tumour showed the presence of pharmacologically active substances and prostaglandin E2-like activity was found in small amounts3. Subsequent examination of the BP8/P1 cells has revealed concentrations of prostaglandin E2 in excess of 100 times that of the fluid. Significant amounts have also been found in another tumour, sarcoma 180 (S180).
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