Abstract
AbstractPurpose Patients who take topical ocular hypotensive medications are often instructed to remove their contact lenses prior to instilling the drug. These instructions have been based upon the known affinity that polymeric material has for the most commonly used ophthalmic preservatives. Newer, preservative‐free agents, such as Saflutan® (tafluprost 0.015mg/ml), offer no direction to patients concerning contact lens wear. This study was conducted to determine if the possibility arises that tafluprost could partition between the solution phase (drug product formulation) and the contact lens polymeric material, thereby potentially impacting pharmokinetics and efficacy.Methods Tafluprost 0.015mg/mL and bimatoprost 0.3mg/mL preservative‐free solutions were added to single contact lens and incubated up to 2 hours at either 25 or 37 C. After the incubation interval, a 0.20 mL aliquot of product was withdrawn and diluted 10X in mobile phase for determination of drug concentration by reverse‐phase ultrahigh performance liquid chromatography (RP‐UPLC).Results Tafluprost and bimatoprost partition from product solution into contact lens material rapidly (within 15 min). At 37 C, for all solution volumes tested, Fsoln for bimatoprost was approximately 2X higher than Fsoln for tafluprost.Conclusion Both tafluprost and bimatoprost partition rapidly from product formulation into soft contact lens material. Tafluprost (logP = 4.2) is more hydrophobic than bimatoprost (logP = 3.2) and partitions more strongly than bimatoprost into contact lens material. This study demonstrates that contract lens wearers should remove lenses prior to instilling the product formulations. Lenses may be reinserted after drop instillation. Commercial interest
Published Version
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