Abstract
Mechanisms controlling noradrenaline secretion from human vasoconstrictor nerves were studied in isolated superfused field-stimulated specimens of peripheral arteries and veins obtained by biopsy from six normotensive individuals. The tissue was preincubated with tritium-labelled noradrenaline, and the evoked rise in efflux of total tritium was used to monitor nerve stimulation induced secretion of endogenous sympathetic neurotransmitter. The results suggest that noradrenaline secretion in vasoconstrictor nerves from normotensive man is normally to about the same extent restricted by two separate local feedback mechanisms, one dependent and one independent of prostaglandin E.
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