Abstract
Summary Studies with polyphloretin phosphate (PPP), a substance that has been reported to block the action of prostaglandins (PGE1 and PGF2α) in certain in vivo and in vitro situations, reveal it has no effect upon PGE1 stimulated cyclic AMP formation in mouse ovaries or rabbit myometrium. Instead, PPP is shown to act at a site subsequent to cyclic AMP formation, tentatively identified as the cyclic AMP dependent protein kinase step. Thus, PPP is not a true prostaglandin antagonist in these tissues, since it does not block the primary PGE1 event. The data presented, combined with the in vivo antiprostaglandin effect of PPP, support our earlier proposal that cyclic AMP is an obligatory intermediate in the action of prostaglandins.
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