Abstract
We examined the effects of TSH, prostaglandin Ex (PGEX) and the prostaglandin antagonists, polyphloretin phosphate (PPP) and 1– acetyl–2- (8-chloro-10,11-dihydrodibenz (b,f) (1,4)- oxazepine-10-carbonyl)hydrazine [SC-19220], on cyclic 3′,5′-adenosine monophosphate (cyclic AMP) formation and the release of hormonal radioiodine in incubated mouse thyroid lobes. Both TSH and PGE1 augmented cyclic AMP formation and thyroid hormone release in this in vitro system; the presence of PGE1 blunted the doseresponse line to the more potent TSH in both assays. PPP and SC-19220 each inhibited induction of cyclic AMP formation and thyroid hormone release by both TSH and PGE1. These findings support our working postulate that thyroidal prostaglandins may play an important role in TSH stimulation of cyclic AMP formation and hormonogenesis in the gland. (Endocrinology 94: 91, 1974)
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