Abstract
Ocular changes induced by irradiation of the pigmented rabbit iris with a ruby pulse laser are mediated partly by prostaglandin and partly by a component resistant to both atropine and indomethacin. Topical application of local anaesthetics, such as benoxinate, partly inhibited, whilst the combined use of benoxinate and indomethacin or the intracameral instillation of tetrodotoxin prevented the ocular response. These observations emphasize the likelihood of a non-cholinergic neurogenic component in the mediation of the response of the rabbit eye to trauma.
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