Abstract
Application of ruby laser light to the pigmented rabbit iris elicits an acute, dose-related injury response which is characterized by a pupil constriction and a transient increase in intraocular pressure and is accompanied by an increased infiltration of blood-plasma proteins and a release of prostaglandin-like material into the aqueous humour. In unilaterally sympathetically denervated eyes the peak intraocular pressure and pupil changes and the aqueous prostaglandin levels are notably higher than in contralateral normal eyes following laser irradiation. Indomethacin, a drug which prevents prostaglandin formation, inhibited the intraocular pressure and pupil responses in both eyes but it did not reduce the magnitude of difference in sensitivity between the sympathetically denervated and control eyes. The results suggest that the increased sensitivity of the former are not due to the raised prostaglandin levels but are the result of removal of the pupil dilator and vasoconstrictive influences of sympathetic nervous activity.
Published Version
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