Abstract
The products of the arachidonic acid dependent oxidation of benzo(a)pyrene by enzyme preparations from sheep seminal vesicles are the 1,6−, 3,6−, and 6,12− quinones. The metabolites were identified by high performance liquid chromatography and visible spectroscopy. The amount of benzo(a)pyrene converted to quinones by a Tween 20 solubilized preparation during a 15 min period is 43 μM/mg protein. The relative yields of the individual quinones are 1,6 – 25%, 3,6 – 30%, and 6,12 – 45%. Arachidonate dependent benzo(a)pyrene oxidation is strongly inhibited by butylated hydroxyanisole, vitamin E, and diethyldithiocarbamate and moderately inhibited by butylated hydroxytoluene and vitamin C. Epinephrine and lipoic acid are also inhibitors.
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