Prospects for pharmacological screening of oral detoxification drugs with differentiation of targeted pathologies in animal husbandry

Abstract

In the modern livestock sector, the domestic industry of the North-West region, cases of poisoning of animals on farms and large complexes are increasingly occurring. This is primarily due to the intensive use of various synthetic modulators, growth stimulants, fertilizers in the agronomic industry and the excessive use of antibiotics, hormones and other veterinary drugs in animal husbandry.Pharmacological screening of oral detoxification agents with differentiation of target pathologies is a promising direction in the development of domestic animal husbandry. A reasonable choice of sorbents in each individual case of poisoning allows you to quickly achieve a therapeutic effect, reduce the toxic load on the animal’s body, which further ensures sustainable productivity and high quality products. This work highlights the results of some studies on the functional activity of the most common enterosorbents in relation to toxins of various natures.Based on the results of the study, it was noted that with an increase in pH from 2.0 (rennet model) to 7.5 (analogue of the distal small intestine), a release of part of the indicator substance from the pores of the sorbent (desorption) is observed, which reduces its absolute sorption effect [5] . The lowest desorption value was shown by atoxyl (8.5%) and phytopos (9.0%). That is why these drugs are the most effective oral detoxification agents for toxins with a molecular weight close to methylene blue.The maximum adsorption effect for various poisonings in animals can be achieved by using sorbing agents that are highly selective for a particular toxin. Research on the choice of oral detoxification agents with differentiation of target pathologies significantly expands the database on existing sorbents, makes it possible to prevent and treat poisonings of various types more effectively, and provides opportunities for the combined use of various adsorbent substances.