Prospective study of relationship between deep vein thrombosis and homocysteine related group B vitamins

Abstract

Introduction: Hyper homocysteinemia has been considered as a potential risk factor for deep venous thrombosis (DVT) but it is still controversy. This study was aimed to assess the prevalence of hyper homocysteinemia in our population with DVT. Our second objective was to document the prevalence of folate, Vitamin B6, and Vitamin B12 level in this patient population. Results: Mean serum homocysteine levels among DVT patients was 15.12±5.47 μmol/L. Most of the patients of DVT were from 41-60 years of age group with mean age being 50.11±13.66 years. Of all the patients, 15 patients had homocysteine level above the 15 µmol/L, 22 had folic acid level below 3 ng/ml, 14 had vitamin B12 level below 150 pmol/L, and 3 had vitamin B6 level below 30 nmol/L. In the hyper homocysteinemic group, eleven patients had low folic acid level, ten had low vitamin B12 level and two had low vitamin B6 level.Conclusions: Hyper homocysteinemia and related Vitamin B group deficiency are risk factors for Deep vein thrombosis. Hyper homocysteinemia and risk of DVT, this correlation is high among older age group and female patients.