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Abstract
The management of osteoarthritis of the knee runs the spectrum of care from a variety of conservative treatments often culminating in total joint arthroplasty. We initiated a large prospective study to evaluate whether autologous adipose derived stromal vascular fraction (SVF - rich in stem cells) therapy is a safe and effective option.
Highlights
Multiple peer-reviewed publications exist showing that adipose derived stromal vascular fraction containing adult mesenchymal stem cells may improve the condition of inflammatory knee conditions [1,2,3,4,5].Animal studies show double-blind examples of significant improvements in using adipose derived stem cells for degeneration and injuries [6].Multiple studies suggest that allogeneic stem cells may be efficacious and safe [7,8,9,10,11]
Deployment of autologous stromal vascular fraction (SVF) represents a simple surgical procedure that can be safely performed in an adequate outpatient environment under straight local anesthesia and demonstrates very good outcomes even in difficult cases of chronic knee arthritis
While the trends were the same in all categories, we demonstrate body mass index (BMI) 18-25 compared to BMI 30+ (Figure 4a and Figure 4b)
Summary
A patient funded prospective study of 2,586 patients from a network of physicians participated in an IRB approved study using autologous stromal vascular fraction SVF (ClinicalTrials.gov as NCT10953523). All patients were treated with a standardized surgical protocol to harvest lipoaspirate, isolate and deploy autologous SVF. Data was collected using an online registry and patients were followed-up via an automatic online database collection service. Significant improvement was seen at 1 and 2 years - meaning less pain and greater ease of mobility. There was no difference between male or female outcomes (82% overall improvement). All BMI levels showed improvements though higher BMIs had less improvement. There was no difference in outcomes between SVF alone or with PRP added to SVF. Improvement was the same regardless of payment or receiving free care. There were very few adverse events and those that did occur were largely very minor or treatable
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