Abstract
Mid-infrared (MIR) fibre-optics may play a future role in in vivo diagnosis of disease, including cancer. Recently, we reported for the first time an optical fibre based broadband supercontinuum (SC) laser source spanning 1.3 to 13.4 μm wavelength to cover the spectral 'fingerprint region' of biological tissue. This work has catalysed the new field of fibre MIR-SC and now very bright sources equivalent to a 'few synchrotrons' have been demonstrated in fibre. In addition, we have made record transparency MIR fibre for routeing the MIR light and reported first-time MIR photoluminescence (with long lifetime) in small-core, rare earth ion doped, MIR fibre - an important step towards MIR fibre lasing at >4 μm wavelength for pumping fibre MIR-SC. First time fibre MIR-SC spectroscopic imaging of colon tissue is described at wavelengths in the 'fingerprint region'.
Highlights
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Shown are the non-diffraction-limited power spectral density (PSD) for a 1500 K blackbody emitter imaged using a range of commercial reflective microscope objectives with magnifications of 15×, 25× and 74×
Compared are the calculated PSD of wideband blackbody thermal emitters (e.g. GloBar®) and representative synchrotron (SR) MIR output calculated for a 0.5 A beam current.[36]
Summary
Users may download and print one copy of any publication from the public portal for the purpose of private study or research. Correction for ‘Prospective on using fibre mid-infrared supercontinuum laser sources for in vivo spectral discrimination of disease’ by Angela B.
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