Prospective of microwave-assisted and hydrothermal synthesis of carbon quantum dots/silver nanoparticles for spectrophotometric determination of losartan potassium in pure form and pharmaceutical formulations

Abstract

Abstract The present study included green chemistry applications in the preparation of carbon quantum dots/Silver nanoparticles (CQDs/Ag nanocomposite). The suggested methods have been applied with the use of microwave and hydrothermal to create quantum dots prepared from glucose and natural orange juice that used in the reduction and stabilization of Ag ion to synthesize CQDs/Ag nanocomposite (I) and CQDs/Ag nanocomposite (II) respectively (method (I) and (II)). CQDs/Ag nanocomposite was used as a colorimetric sensor for the sensitive determination of losartan potassium (LoK) drug belongs to Angiotensin II receptor blockers. The interaction between the studied drug and CQDs/Ag nanocomposite was measured at λ max of 409, 417 nm for the method (I) and method (II) respectively. Good linear relationships were obtained, under optimum conditions in the range of (1–26), (2–46) µg.mL−1 (R = 0.9973, 0.9994), the recovery average was 99.65% and 97.62%, the relative standard deviation not more than 0.76% and 1.11% for method(I) and method(II) respectively. The methods were successfully applied to the estimation of losartan potassium in pharmaceutical formulations (tablets). The proposed method is environmentally safe because it uses environmentally friendly and non-toxic raw materials and the solvent used is water.