Prospective comparative study on effects of oral clonidine and oral midazolam as pre-medicants for general anaesthesia

Abstract

Aim: The purpose of the present research to compare between the effects of oral clonidine and oral midazolam as a pre-medication for initiating General anesthesia. Methodology: A comparative study between midazolam and Clonidine as a premedication for general anesthesia was conducted on 100 patients of each group. The study was performed on Dr. Moopen's Medical College, Wayanad, Kerala. India and duration was from January 2022 to September 2022. All the patients belonged to ASA class I or II. The age of patients ranged from 20 - 60 years. On the day before the operation pre-operative assessment was carried out. Results: Majority of cases in both the groups were in the age group of 20-30 years (56%). Gender wise distribution shows 40% cases were males and 60% were females. The sedation score, apprehension score and excitement score in both the groups before and after induction was statistically significant. There is no significant difference in dose requirement of Thiopentone sodium for induction between midazolam and clonidine group. The amnesia score shows that midazolam produces more potent and perfect amnesia as compared to clonidine. Amnesia score in both the groups was statistically significant.