Efficacy of preoperative melatonin and ramelteon (melatonin agonist) therapy on dose requirement of propofol for induction of general anaesthesia: A comparative prospective study

Abstract

General anesthesia is a medically induced coma with loss of protective reflexes resulting from the administration of one or more general anesthetic agents our study is to compare the role and efficacy of preoperative oral Melatonin, Ramelteon, and Midazolam therapy on the dose requirement of induction agent (Propofol). : Were divided into Case and Control Group. Case group of people were given Oral Melatonin (6mg)/Ramelteon (8mg) as premedication 2 to 3 hours before induction in OT and the control group were given oral Midazolam (5mg). After checking all the parameters, the induction process Total number of 60 people was randomly selected from ASA grade I & grade II, aged between 20 to 50 years, started with injection Propofol slowly in intravenous route and subsequently the BIS level up 60 was noted. After complete reversal of General Anesthesia, post-operative sedation level of the patient was measured using Ramsey sedation scale. Melatonin and Ramelteon shows significant reduction in preoperative anxiety state of the patient in comparison to Midazolam, measured by Hamilton Anxiety rating scale. The sedation status was measured by Ramsey Sedation Scale for each drug and it shows no significant difference between the drugs.: Considering absolute values and statistical values, all three drugs are potent premedication in general anesthesia. Among them, Melatonin is most potent in reducing the induction dose of injection Propofol. Ramelteon is also effective in reducing induction dose of Propofol. Along with, both are potent anxiolytic agent in pre-operative state.