Abstract
Objective: Retinol Binding Protein–4 (RBP–4) is an adipokine that has been identified as a novel regulator of insulin resistance. It has been suggested that insulin resistance might be associated with the pathophysiology of preeclampsia. The aims of this study were to determine whether the maternal serum levels of RBP-4 differ between patients with preeclampsia and those with normal pregnancies and to explore the relationship between the severity of disease and serum concentrations of RBP-4. Method: This case-control study included two groups: 1. Patients with preeclampsia (n=27) and 2. Patients with normal pregnancies (n=27). All subjects enrolled in the study were in their gestational age of 30 weeks or more. Serum RBP-4 concentrations were determined by ELISA. Results: Patients with preeclampsia had a higher serum concentration of RBP-4 than that of normal pregnant women (p < 0.001). When women with preeclampsia were categorized as those with preeclampsia and severe preeclampsia, no significant difference was observed in concentration of serum RBP-4 (p= 0.272). Conclusions: Our results support a role of RBP-4 in the pathogenesis of preeclampsia
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