Abstract
Lipidomics, a rapidly developing research field, has been widely studied in many non-cancer areas, and in some cancers. Taking prostate cancer as an example, this article has concisely reviewed applications of lipidomics in cancer research. Lipidomics is able to identify a few out of thousands individual lipid species in bio-fluids as biomarkers in diagnosis of prostate cancer with high sensitivity, specificity and accuracy. This technology has been also used in studying the pathogenesis of prostate cancer by combining data of lipid profiling with lipid metabolites and pathways strategy. Importantly, lipidomics can provide details of lipid compositions different between prostate cancer and benign prostate, which will greatly help to make strategy in prevention and treatment of prostate cancer.
Highlights
Prostate cancer is a disease that affects men worldwide and places a medical and socioeconomic burden on modern society
Lipidomics has been widely studied in many non-cancer areas, and in some cancers, such as in pancreatic adenocarcinoma, thyroid cancer, colon cancer, hepatocellular carcinoma, glioblastoma, [2,3,4,5,6] and prostate cancer [1,7,8]
If three lipid species, LPC(18:1), LPC(20:4) and PC(40:7) are used together, the combination would provide a sensitivity of 91.5%, specificity of 84.3% and accuracy (ROC area) of 95.9% in differentiating patients with prostate cancer from controls
Summary
Prostate cancer is a disease that affects men worldwide and places a medical and socioeconomic burden on modern society. Lipid profile, in the context of composition, configuration and quantity of individual species, groups and classes of lipids in prostate cancer cells must be distinguishable from that in normal prostate cells.
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