Proses şartlarının polivinilpirolidon polimerinin düşük toksisiteli solventler ile elektroeğirilme davranışı üzerindeki etkisi

Abstract

Due to its properties such as biocompatibility, water solubility and stability, polyvinylpyrrolidone (PVP) becomes more and more attractive for biomedical applications. This polymeric material is used in various applications such as pharmaceutical aid, complexing agent or solubilizer. PVP nanofibers are often produced using PVP solutions in solvents with high toxicity such as dimethylformamide (DMF). The aim of this study is to investigate the effect of process parameters on the electrospinning behavior of polyvinylpyrrolidone in solvents with lower toxicity such as dimethylsulfoxide (DMSO) or ethanol. Therefore, solutions of PVP in ethanol, PVP in DMSO or PVP in binary solvent systems such as DMSO/ethanol or DMSO/acetone were prepared and electrospun. The effect of process parameters such as voltage, flow rate, tip-to-collector distance were examined. A solution parameter, the polymer concentration was also considered. The morphology and diameter of the electrospun nanofibers were characterized by scanning electron microscopy (SEM). The effect of the solution viscosity was also questioned. Nanofibers with a homogeneous cylindrical morphology were obtained in the case of PVP in ethanol solutions for a polymer concentration of 7 wt.%. The process parameters were: a voltage of 15kV, tip-to-collector distance of 15 cm and a flow rate of 1.25 mL/h. PVP in DMSO solutions didn’t allow the obtention of solid nanofibers on the collector where a wetness zone appears. This shows that the solvent could not evaporate quickly. A wetness was also observed with PVP solutions prepared using binary solvent systems where a more volatile solvent such as ethanol or acetone was used.