Abstract
Propylthiouracil is one of several thionamide drugs used in the treatment of hyperthyroidism. It works by inhibiting the thyroid peroxidases (TPO), which catalyze the iodination of tyrosine residues in thyroglobulin and the oxidative coupling of iodinated tyrosines. Inhibition of iodination is competitively antagonized by iodide at low drug concentrations, but not at higher drug concentrations …
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