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Abstract
Oral propranolol (PRN) has recently been shown to be highly effective for infantile hemangiomas (IHs), and is currently recommended as the first-line treatment of complicated IHs. However, no pharmacokinetic parameters have ever been reported for infants who received PRN treatment for IHs, and the therapeutic mechanism(s) still remain unclear. In this study, we found that plasma PRN concentration was affected by the frequency of administration of PRN. A single daily administration of PRN (1mg/kg/d) resulted in an early elevation of plasma PRN compared to administration of the same dose divided into two times daily.
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