Abstract
Polymeric films containing propranolol HCl were prepared by dissolving the drug in the aqueous colloidal polymer dispersion, Eudragit RS 30D, before casting and drying. The release of propranolol HCl was studied as a function of drug content, Eudragit RS 30D/RL 30D ratio, plasticizer content, method of film preparation and storage humidity. The addition of the more hydrophilic Eudragit RL 30D increased the permeability of the films. The amount of water-soluble plasticizer, triethyl citrate, added had a pronounced effect on drug release. The release was rapid at low and high plasticizer concentrations because of incomplete coalescence of the latex and leaching of the plasticizer. The drug release from latex-cast films was faster when compared to that from solvent-cast films.
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