Abstract
The aim of this study was to compare propofol produced EEG burst suppression with isoflurane produced burst suppression in rabbits and to see whether rabbits can serve as models in studying the effects of different anaesthetics on human EEG. We recorded EEG of eight rabbits anaesthetised with isoflurane and propofol. The isoflurane bursts had higher amplitude than propofol bursts (P < 0.005). Isoflurane bursts appeared on distinct DC-shifts while propofol bursts were on slow waves. The EEG patterns were, however, different from those seen in humans. Rabbits did not have the rhythms seen in humans. We conclude that rabbits can be used to study the EEG effects of anaesthetics, such as the timing properties and reactivity of burst suppression pattern. However, this model seems less promising in the study of rhythmic activity seen in human EEG during burst suppression.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.