Prophylactic Effect of Intravenous Administration of Sufentanil on Propofol Injection Pain

Abstract

In most of the patients, propofol caused pain or discomfort during injection. Injection of various intravenous drugs prior to propofol is one of the methods for relieving propofol-induced pain. Different sources suggested unclear and confounding results on the effect of Sufentanil injection on the pain from propofol. Prophylactic effect of sufentanil on the severity of pain from propofol injection was investigated in this double-blind study in which 118 relevant patients have participated. The patients were randomly given 5 micrograms of Sufentanil to 59 patients and normal Saline to the remaining 59 ones. Pain severity, systolic and diastolic blood pressures, mean arterial pressure and heart beat ratewere measured before and afterpropofol injection. The pain during injection was found to be signif icantly lower in the Sufentanil group. Sufentanil also reduced systolic and diastolic blood pressures, mean arterial pressureand heart rate.