Properties and bioaccessibility of arsenic sulphide nanosuspensions

Abstract

Dissolution tests of the nanosized realgar particles prepared by the novel wet milling technique are described in this paper. For nanomilling of arsenic sulphide As4S4, laboratory Perl Mill PML2 (Bühler) was used. The specific surface areas increased from 0.2 to 34.2m2/g during milling. A nanosized, monomodal distribution with a mean particle size of 146–198nm was obtained. The ξ-potential values from −52 to −38mV were determined. Dissolution experiments in simulated gastric and intestinal fluids demonstrate that the soluble arsenic from As4S4 available for absorption into the bloodstream is greater than 10%.