Properdin.

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Editorial1 September 1957PROPERDINPAUL W. CLOUGHPAUL W. CLOUGHSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-47-3-599 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough acquired immunity has been extensively studied and much has been learned regarding the role of the protective substances in the blood, the factors concerned with natural (spontaneous) resistance to infection are poorly understood. Recent studies, particularly by Pillemer and his associates, have demonstrated and partly characterized a previously unrecognized constituent of the serum which seems to play an important role in the defense from infection and probably in other biochemical reactions as well.This substance, termed properdin by Pillemer,1was first recognized during a study of complement. In an attempt to isolate the third constituent of complement, C'3 according...1 Pillemer L: The properdin system and immunity. I. Demonstration and isolation of a new serum protein, properdin, and its role in immune phenomena, Science 120: 279-285, 1954. CrossrefMedlineGoogle Scholar2 Pillemer L: The properdin system and immunity. III. The zymosan assay of properdin, J. Exper. Med. 103: 1-13, 1956. CrossrefMedlineGoogle Scholar3 Pillemer L: The properdin system and immunity. II. Interaction of the properdin system with polysaccharides, Science 122: 545-548, 1955. CrossrefMedlineGoogle Scholar4 WardlawPillemer ACL: The properdin system and immunity. V. The bactericidal activity of the properdin system. J. Exper. Med. 103: 553-575, 1956. CrossrefMedlineGoogle Scholar5 Wedgewood RJ: The properdin system and immunity. VI. The inactivation of Newcastle disease virus by the properdin system, J. Exper. Med. 104: 707-725, 1956. MedlineGoogle Scholar6 GinsbergHorsfall HSFL: Labile component of normal serum which combines with various viruses. Neutralization of infectivity and inhibition of hemagglutination by component, J. Exper. Med. 90: 393-407, 1949. CrossrefMedlineGoogle Scholar7 McCarthyGerner KWD: Two heat labile factors in normal sera which neutralize variola virus, Brit. J. Exper. Path. 33: 529-536, 1952. MedlineGoogle Scholar8 Hinz CF: The properdin system and immunity. IV. The hemolysis of erythrocytes from patients with paroxysmal nocturnal hemoglobinuria, J. Clin. Investigation 35: 453-457, 1956. CrossrefMedlineGoogle Scholar9 Hinz CF: The requirement for the properdin system in the hemolysis of human erythrocytes treated with tannic acid, J. Clin. Investigation 34: 912, 1955 (abstract). Google Scholar10 PillemerRoss LOA: Alterations in serum properdin levels following injection of zymosan, Science 121: 732-733, 1955. CrossrefMedlineGoogle Scholar11 Rowley D: Stimulation of natural immunity to Escherichia coli infections. Observations on mice, Lancet 1: 232-234, 1955. CrossrefGoogle Scholar12 Hestrin S: Promotion of peritoneal infection by intravenous levan, Brit. J. Exper. Path. 35: 112-117, 1954. MedlineGoogle Scholar13 Fine J: Relation of bacteria to the failure of blood volume therapy in traumatic shock, New England J. Med. 250: 889-895, 1954. CrossrefMedlineGoogle Scholar14 Frank E: Serum properdin levels in hemorrhagic shock, Proc. Soc. Exper. Biol. and Med. 89: 223-225, 1955. CrossrefMedlineGoogle Scholar15 Pillemer L: Preparation and properties of antihuman properdin rabbit serum, Science 125: 1244-1245, 1957. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1957Volume 47, Issue 3Page: 599-604KeywordsBloodImmunity Issue Published: 1 September 1957 PDF downloadLoading ...