Abstract
A novel propargylic electrophile-induced tandem intermolecular addition-semipinacol rearrangement was developed efficiently under mild conditions. Various allylic silylether substrates as well as Co-complexed propargylic species were applicable to this protocol and gave a series of synthetically useful β-propargyl spirocyclic ketones in moderate to good yields. Its synthetic application was also demonstrated by an efficient construction of the key tricyclic moiety of daphlongamine E.
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