Abstract
1,3-'s a crowd: The facility of the AlCl3-catalyzed Nazarov cyclization of electron-rich aryl dienones was found to be dependent upon the substitution of the diene portion (see scheme). For α,γ-substituted systems, pronounced 1,3-allylic strain in the reactant is alleviated in the transition state for electrocyclization, leading to enhanced reactivity. DFT calculations support this analysis and have proven to be predictive of reactivity.
Full Text 
Sign-in/Register to access full text options
Sign-in/Register to access full text options 
Published version (
Free)
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
