Applications de la théorie de la chromatographie d'adsorption linéaire de Snyder en série hétérocyclique : I. Influence des effets polaires et stériques de substituants divers sur les énergies d'adsorption d'hétérocycles thiazoliques sur alumine

Abstract

Applications of Snyder's theory on linear adsorption chromatography to heterocyclic compounds. I. The influence of the polar and steric effects of various substituents on the adsorption energy of thiazoles on alumina Snyder's theory of linear adsorption chromatography, that was applied to one hundred thiazole derivatives, made it possible to determine experimentally the adsorption energies of the compounds and to compare these with the adsorption energies calculated by means of fixed tables. In a study on thiazoles containing one or two alkyl groups, this comparison enabled us to determine the variations in adsorption energy of the nitrogen atom of the ring due to the polarization effects and to the steric effects induced by the alkyl groups and to relate these effects to the constant relationships which exist between the polarization and steric effects of the substituents. A similar investigation was made on 4-aryl thiazoles with various substituents in the 2-position. In this case variations in the adsorption energy of the molecules due to the polarization effects of the groups substituted para to the phenyl group with respect to the substituents in the 2-position were studied, and the mutual electronic interactions between the various groups were determined.