Abstract
Molecular imaging has been a rapidly developing field of molecular biology. Specific sophisticated approaches have been pursued to effectively monitor the fate of transplanted cells in the body, i.e. retention in target organ, migration routes and cell survival up to their final destination
Highlights
The multimodal imaging based on the promoter reporter systems has been developed over the recent years in in vivo as well as in vitro models
Those ones used in vivo allow tracking of transplanted cells and monitor gene therapy by e.g. visualization of transplanted cells fate
It is important to note, that in vitro studies confirmed that a variety of cardiac specific promoters and specific reporters like, ACTC [25], TNNT2 [26] can be successfully used as promoters, they have not been tested yet in in vivo models
Summary
Promoter Reporter Systems for Imaging of Cells Transplanted into Post-infarcted Heart. We would like to focus on some examples of contemporary reporter systems that are in use to monitor different stem/progenitor cell types that could be applied for pro-regenerative therapy of post-infarction heart. Viral promoter reporter systems have become very popular tools currently used, but one needs to keep in mind that introducing genetic material to the cells or individual organisms can be associated with broad spectra of side effects.
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