Abstract
Proliferative verrucous leukoplakia is classified as a subtype of oral leukoplakia, with a rare incidence and high malignant potential. It is more common in females and in the seventh decade of life, and it has a high recurrence rate. The initial appearance is a white lesion, homogeneous, seemingly innocuous, that develops some erythematous areas, has a verrucous surface, and becomes aggressive with multifocal involvement over time. White woman, 71, had a medical history of heart disease and hypertension and was referred to CAPE/FOUSP for the diagnosis of oral lesions. Intraoral physical examination showed extensive nonremovable white lesions with irregular, indistinct contours that were painless. The palate, bilateral buccal mucosa, and alveolar ridge were affected. Incisional biopsies on the alveolar ridge and buccal mucosa yielded a histological diagnosis of hyperkeratosis suggestive of proliferative verrucous leukoplakia. The patient was referred to LELO for surgical removal of the lesion with CO2 laser.
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